Dhani has reportedly issued divorce proceedings against his wife of four years.
Entertainment news website TMZ claim singer-songwriter Dhani Harrison, 38, has cited irreconcilable differences as a motive for his separation from model turned psychologist Solveig 'Sola' Karadottir.
The musician, Harrison's only child with second wife Olivia Arias, is understood to have filed a petition to end their marriage in Los Angeles a week ago.
TMZ also claim the cost of spousal support and legal fees will be dictated by a prenuptial agreement entered by both parties prior to their marriage.
Dhani married Solveig, the daughter of deCODE Genetics co-founder Kári Stefánsson, at the Harrison's Friar Park estate in Henley-on-Thames in June 2012.
Guests at the low-key ceremony included Hollywood star Tom Hanks, British actor Clive Owen and his father's two surviving bandmates, Ringo Starr and Sir Paul McCartney.
Solveig also wore an embroidered bridal gown designed by McCartney's fashion designer daughter, Stella.
The statuesque former model walked down the aisle to Led Zeppelin track The Rain Song before exchanging vows with Dhani in Friar Park's garden amphitheater.
Their picturesque wedding took place 11 years after Harrison lost his battle with cancer in November 2001, and Dhani later admitted he wishes his father had been there to witness his special day.
He told MailOnline: ‘When he died I remember thinking we’d left nothing unsaid and that was good. But then you get older, and there have been so many times I miss my dad.
'Getting married, going on your stag do – pick any moment and you wish he was there.’
He added his life has been marked by losing heroes; as well as his father’s death, he cried at those of Ayrton Senna and Kurt Cobain.
‘Death crushes you. But that’s what forms you – you get hammered and hammered and they heat you up and hammer you, heat you up and hammer you, and eventually you’re a sword. You’re brave, you’re ready to be your own man.’