Paul is slated to play a fund raising event tonight to benefit the Tobin Center for the Performing Arts.
The Tobin Center opened last month after a seven-year effort to transform the old municipal building into a world-class performing arts venue.
Officials said landing the McCartney concert helps put the center on the map.
KSAT interviewed Michael Fresher, president and chief executive officer for the Tobin Center, when the concert was announced in July.
"Our board was very supportive of getting the biggest rock star in the world," said Fresher. "It's absolutely unheard of and it's a once-in-a-lifetime opportunity for the folks in San Antonio to not only see one of the only remaining Beatles, but also to support the Tobin Center."
The Beatles legend easily sells out 50,000-seat arenas but this will be a rare intimate performance as the Tobin Center performance hall seats only 1,750.
McCartney and his band are scheduled to take the stage 8 p.m. This will be McCartney's first appearance in San Antonio since 1993.
The concert tops off a month-long grand opening celebration for the new $203 million performing arts center located in the heart of downtown San Antonio.